I know there are some very original games out there but check out Scribblenauts.
Youtube link.
Wow. This is different. This is genius. This is simply awesome.
You can do pretty much anything with it.
If you like doing stuff, like I do, you probably want to check this out.
The game won Best of E3 '09 on IGN.com.
Yet another Youtube link.
That video explains how cool it actually is.
God versus freaking Cthulhu? That's epic.

I'm impressed. This looks like the DS game I have been waiting for. I can't wait to mess around with it.